Music icon David Bowie, whose illustrious career lasted five decades with hits like "Fame," ''Heroes" and "Let's Dance," died Sunday at the age of 69, his U.S. agent, Steve Martin, confirmed to CBS News in London.
Bowie's website, davidbowie.com, says the innovative singer, songwriter and actor "died peacefully today surrounded by his family after a courageous 18 month battle with cancer. While many of you will share in this loss, we ask that you respect the family's privacy during their time of grief."
Bowie turned 69 on Friday, the same day he released an album called "Blackstar."
Bowie, who was born David Jones, came of age in the glam rock era of the early 1970s.
He had a striking androgynous look in his early days and was known for changing his looks and sounds.
The stuttering rock sound of "Changes" gave way to the disco soul of "Young Americans," co-written with John Lennon, to a droning collaboration with Brian Eno in Berlin that produced "Heroes."
He had some of his biggest successes in the early 1980s with the stylist "Let's Dance," and a massive American tour.
"My entire career, I've only really worked with the same subject matter," Bowie told The Associated Press in a 2002 interview. "The trousers may change, but the actual words and subjects I've always chosen to write with are things to do with isolation, abandonment, fear and anxiety -- all of the high points of one's life."
His performance of "Heroes" was a highlight of a concert for rescue workers after the 2001 World Trade Center attacks.
"What I'm most proud of is that I can't help but notice that I've affected the vocabulary of pop music. For me, frankly, as an artist, that's the most satisfying thing for the ego."
Bowie kept a low profile in recent years after reportedly suffering a heart attack in the 2000s.
He made a moody album three years ago called "The Next Day" -- his first recording in a decade which was made in secret in New York City.
"Blackstar," which earned positive reviews from critics, represented yet another stylistic shift, as he gathered jazz players to join him. He released a music video on Friday for the new song "Lazarus," which shows a frail Bowie lying in bed and singing the track's lyrics.
The song begins with the line: "Look up here, I'm in heaven."
Tributes poured in for the singer. British astronaut Tim Peake tweeted about his sadness from outer space aboard the International Space Station, saying "his music was an inspiration to many."
British Prime Minister David Cameron tweeted that Bowie's death is "a huge loss." He wrote he had grown up listening to and watching Bowie and called the singer a "master of reinvention" and a pop genius who kept on getting it right.
Kanye West said on Twitter that Bowie "was one of my most important inspirations, so fearless, so creative, he gave us magic for a lifetime."
Bowie was married to international supermodel Iman since 1992.
He was inducted into the Rock and Roll Hall of Fame in 1996, but he didn't attend the ceremony.
Madonna, another artist who knew something about changing styles to stay ahead of the curve, accepted for him and recounted how a Bowie concert changed her life when she attended it as a teenager.
David Byrne, of the art rockers Talking Heads, inducted Bowie and said he gave rock music a necessary shot in the arm. "Like all rock 'n' roll, it was visionary, it was tasteless, it was glamorous, it was perverse, it was fun, it was crass, it was sexy and it was confusing," Byrne said.