I'm now up to 3 shots a day; Lupron in the morning, Gonal F in the morning, then Menopur in the evening. Gonal F didn't hurt, but the needle is a bit bigger so I had to push a little more, which is a very strange feeling. I also numb the area with a cold pack and that seemed to help. But, since the first 2 were a breeze, I was shocked when I got to Menopur. The needle went in fine, but when it came time to push the medicine in, I was brought to tears. That stuff burns! Turns out a lot of other people agree, and their advice is to push the medicine in slow. I gave myself the shot last night slowly and while I held my breath during the entire shot, there were no tears. It didn't hurt nearly as badly.