Georges Niang scored 16 of his 18 points in the second half and had nine rebounds to help lead No. 13 Iowa State to a 64-59 victory over Oklahoma State on Saturday.
Niang shot 7 of 10 shots and grabbed all of his rebounds after halftime. Monte Morris and Matt Thomas each scored 16 points for the Cyclones (17-6, 6-4 Big 12).
Jeffrey Carroll scored 18 points and added seven rebounds for Oklahoma State (11-12, 2-8), which lost for the fourth time in five games and eighth in 10.
Iowa State led 48-35 with 9:59 remaining, but Oklahoma State went up 55-54 on Tavarius Shine's 3-pointer with 3:22 left.
After the Cyclones regained the lead, Carroll's 3 with 1:42 to play tied it at 58-58, but Niang scored on a layup with 1:13 left to make it 60-58.
OSU's Mitchell Solomon connected on 1 of 2 free throws with 50 seconds left to make it a one-point game, but Niang answered with a layup with 34 seconds to go and Morris sank two free throws with 13.5 seconds to go to clinch it.
Each team was missing a key contributor. Iowa State senior forward Jameel McKay sat out the game after he was suspended indefinitely by the team for violating team rules. Junior Deonte Burton made his first start of the season for McKay and scored 11 points and added four steals.
McKay was averaging 12.4 points and 9.0 rebounds a game, with 10 offensive rebounds in his last two games.
For Oklahoma State, freshman point guard Jawun Evans didn't play because of a shoulder injury he aggravated in the Cowboys' 63-61 overtime loss at Texas Tech on Wednesday. Evans, who averages 12.9 points, 4.4 rebounds and 4.9 assists, is considered day-to-day.
Oklahoma State led 27-24 early in the second half when Iowa State used a 10-2 run over the next five minutes to go up 34-29 on Thomas' 3-pointer with 14:44 remaining. That marked the Cyclones biggest lead to that point.
The Cowboys got within 36-33 on Tyree Griffin's long jumper with 13:22 left, but Iowa State reeled off a 12-3 run to establish a 13-point advantage when Thomas sank two free throws with 9:59 to go.
Oklahoma State responded with an 11-1 run, pulling within 49-46 on Carroll's 3-pointer from the right corner with 7:10 remaining.
Iowa State: Entering the game shooting 37.0 percent from 3-point range, the Cyclones connected on 10 of 18 from beyond the arc. Matt Thomas shot 4 for 6 on 3s, giving him a 3-point shooting percentage of 57.1 (16 for 28) over his past four contests.
Oklahoma State: Each of the Cowboys' last three losses, including a 63-61 OT defeat at Texas Tech on Wednesday and a 69-65 loss to No. 15 Baylor on Jan. 27, have been by fewer than five points.
Iowa State: On the road Wednesday at Texas Tech.
Oklahoma State: On the road Monday at TCU.