Vionise Pierre-Louis scored 20 points, Maddie Manning had 18 and No. 20 Oklahoma extended Kansas' losing streak to 17 straight in a 72-66 victory on Saturday.
The Sooners have won 10 of their last 11 meetings between the two teams in Lawrence.
Pierre-Louis' rebound and basket put Oklahoma up 63-55 with 3:11 to play but Kansas pulled to 66-64 at the 1:12 mark on Lauren Aldridge's jumper. Gioya Carter answered with two free throws for a four-point lead and the Sooners got a stop at the other end.
T'ona Edwards was fouled and hit 1 of 2 from the stripe for a five-point advantage with 27 seconds left.
Peyton Little added 11 points for Oklahoma (18-8, 9-6 Big 12). Pierre-Louis was 8 of 9 from the field.
Aldridge led Kansas (5-21, 0-15) with 20 points and Timeka O'Neal made five 3-pointers for 15 points.
Kansas hit 11 of 27 3-pointers which was the most made by an Oklahoma opponent this season.