Maddie Manning scored 21 points and Peyton Little had 13 of her 16 in the fourth quarter to lead No. 20 Oklahoma to a 78-63 win over Iowa State on Wednesday night.
Pierre-Louis added 15 points and Gabbi Ortiz 14 for the Sooners (16-5, 7-2), who won their sixth-straight at home.
Little hit a 3-pointer to open the fourth quarter and put the Sooners up 56-48. Heather Bowe answered with a 3 and Seanna Johnson's layup pulled the
Cyclones back within three. Little had another 3 in a 6-0 burst and then scored five-straight points as the Sooners pushed the lead to 71-59 with 2:29 to play.
Johnson led Iowa State (11-9, 2-7) with 17 points and Jadda Buckley had 15.
Ortiz and Madding each hit two 3s for a 12-0 run that put Oklahoma up 20-6 late in the first quarter. Iowa State cut the deficit to 38-28 at the half.
Both teams shot better than 55 percent in the second half with a combined eight turnovers.