The Oklahoma State Department of Health reported nine more people have died from the flu.
The number of Oklahoma deaths related to the flu has risen to 45 since the start of September.
About 2,314 Oklahomans have been hospitalized due to the flu, according to the Oklahoma State Department of Health.
Influenza is a highly contagious respiratory illness caused by a virus which is spread by infected people coughing, sneezing or touching a surface handled by others. Its impact can be severe in some cases, especially among seniors, young children, pregnant women and people with underlying medical conditions, according to the CDC.
More: Oklahoma Doctors Warn Of Flu Shot Importance This Season
The CDC states the best way to prevent the flu is to get vaccinated.
The OSDH recommends staying home for at least 24 hours after the fever is gone. Avoid going to work, school, social events and public gatherings as well as traveling and shopping. The fever should be gone without the use of a fever-reducing medicine, such as acetaminophen before returning to a regular routine. To prevent the spread of the flu, the public is reminded to cover coughs and sneezes with a tissue and wash hands often.