A 6-year-old boy was killed in a head-on collision caused by a driver going the wrong way on the Kilpatrick Turnpike.
The crash occurred near the Western exit around 8:30 p.m. Sunday.
Authorities said Saxton Watley of Edmond died at the scene from massive injuries.
He was a kindergarten student at Angie Debo Elementary in Edmond.
"It's a huge loss, a lot of tears this morning," Susan Parks-Schlepp, spokesperson for the Edmond School District said. Students and teachers were deeply heartbroken to learn of the accident.
Watley's 9-year-old brother, Stephen, and their mother Shavon McNack-Watley were also injured when a driver going the wrong way on the turnpike smashed head-on into their SUV.
Authorities said it appeared as though the mother tried to avoid the truck coming toward them.
"When you see young kids involved in those kinds of situations, I mean it really tugs at your heart strings," said Captain Paul Timmons of the Oklahoma Highway Patrol.
Initial reports from OHP indicated 44-year-old Kelly Corn was under the influence of medications when he crashed into the family.
Troopers said he was also involved in a hit-and-run accident in the parking lot of a restaurant near Pennsylvania Avenue and Memorial Road just before the deadly collision.
"He was confronted by several of the employees there at the business and he left the scene and got on the interstate going the wrong way," Timmons said. He traveled eastbound in the westbound lanes until hitting the SUV, Timmons added.
The Edmond School District is trying to explain what happened by sending home sealed letters to every parent at Angie Debo Elementary.
"Our hearts are certainly with this family and everything they are going through," said Parks-Schlepp.
The school is also offering counselors for students and staff in the coming days.
News 9 has been told the Stephen Watley and Shavon McNack-Watley underwent surgery at a local hospital.
At last check, Corn was listed in fair condition. He is facing charges of failure to obey traffic signals in the area.
OHP said additional charges are pending a blood test.