Mitchell Shults escaped the Pontotoc County Jail on Wednesday evening and has not been seen since, police said.
Shults, 33, was last seen around 6:00 p.m. on Wednesday wearing gray sweatpants, a dark colored jacket, with a gray hood underneath, and a white T-shirt.
He was driving a stolen gray 2003 Harley Davidson motorcycle with the license plate number 3A3319.
Shults, who was facing a life sentence, is considered dangerous, police said.
Shults is described as a white male about 6 feet, 5 inches tall, brown hair, blue eyes, with a goatee and mustache. He has a circle tattoo representing the Aryan skinhead group on the right side of his neck and writing on the left side of his neck.