Vitals: Oklahoma State Cowboys at Iowa State Cyclones

No. 2 Oklahoma State Cowboys (10-0, 7-0) at Iowa State Cyclones (5-2, 2-4)
7 p.m., Nov. 18
Jack Trice Stadium, Ames, Iowa

Statistical Leaders:

Injury Report:

Oklahoma State: WR Michael Harrison (day-to-day, ankle); WR Hubert Anyiam (out, foot); OL Jonathan Rush (out, knee); CB Devin Hedgepeth (out, Achilles); FS Johnny Thomas (out, academics).

Iowa State: RB Shontrelle Johnson (out, neck); OL Brayden Burris (out, leg); OL Shaban Dika (out, knee); WR Donnie Jennert (out, academics); DE Roosevelt Maggitt (out, knee); QB Jerome Tiller (out, academics); DB Earl Brooks (out, knee); TE Ricky Howard (out, knee).

Where to find it…

On TV: ABC-HD

On Radio: Cowboy Radio Network

What you need to know…

It's officially uncharted territory for the Oklahoma State. For the first time in school history, the Cowboys are 10-0 and ranked No. 2 in the BCS Rankings, in the driver's seat for a berth in the BCS National Championship. Against Texas Tech, OSU cracked the 60-point mark for the third time this season and scored more than 49 in the first half for the second time this season. However, it's not just their offense getting it done, three times this season the Cowboys have shut out an opponent in the first half and leads the nation in turnover margin.

The Iowa State Cyclones have struggled in essentially all facets of the game this season, ranking in the bottom half of the conference in nearly every statistical category. ISU ranks last in the conference in scoring offense (24 points scored), while ranking fifth in scoring defense (29.8 points allowed). Perhaps the most troubling, especially going into this matchup, the Cyclones are dead last in the conference in turnover margin, giving the ball away 23 times.

Who you need to watch…

With Stanford's loss and his continued excellence, Brandon Weeden inserted himself into the talk in the Heisman Trophy race. For the third time this season, the 28-year-old quarterback passed for more than 400 yards and sits 149 yards behind Zac Robinson for the Cowboys' career passing record.

Joseph Randle has been the key to keeping the OSU offense balanced this season. The sophomore from Tulsa is third in the conference in rushing, averaging nearly 100 yards per contest and averages 5.9 yards per carry.

Oklahoma State has been a turnover machine defensively, perhaps most notably defensive backs James Thomas and Brodrick Brown. The pair is tied for third in the conference in interceptions with three each, leading a team that has 10 players with pick this year.

Steele Jantz lost his starting position two games ago and was replaced by redshirt freshman quarterback Jared Barnett. Coincidentally, Iowa State has won the last two contests with Barnett amassing 536 yards between the two contests.

Linebacker Jake Knott may be one of the lone bright spots on the Iowa State defense, ranking third in the conference with total tackles with 84. The junior has also come up with 3.5 tackles for loss, forced two fumbles and came up with one interception.